E02-02: Prognostic and predictive markers in lung cancer-emphasis on receptor tyrosine kinases egfr and met
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چکیده
منابع مشابه
Molecular Prognostic and Predictive Markers in Lung Cancer
Lung cancer is the most common type of cancer in the Western World and there has been systematic effort to find markers with prognostic and predictive significance. Molecular biology is lately being used in order to find markers that are highly sensitive, specific and associated with survival. This review presents recent data regarding the numerous studies that have been conducted in this field...
متن کاملMolecular Markers with Predictive and Prognostic Relevance in Lung Cancer
Lung cancer accounts for the majority of cancer-related deaths worldwide of which non-small-cell lung carcinoma alone takes a toll of around 85%. Platinum-based therapy is the stronghold for lung cancer at present. The discovery of various molecular alterations that underlie lung cancer has contributed to the development of specifically targeted therapies employing specific mutation inhibitors....
متن کاملPrognostic and Predictive Markers in Cancer
The elucidation of the human genome and advances in knowledge about molecular abnormalities, signaling pathways, influence of the local tissue milieu and the relevance of genetic polymorphisms offer hope of designing more effective, individualized cancer treatment plans. Although the scientific and medical literature is replete with reports of putative prognostic or predictive markers for cance...
متن کاملCBL Is Frequently Altered in Lung Cancers: Its Relationship to Mutations in MET and EGFR Tyrosine Kinases
BACKGROUND Non-small cell lung cancer (NSCLC) is a heterogeneous group of disorders with a number of genetic and proteomic alterations. c-CBL is an E3 ubiquitin ligase and adaptor molecule important in normal homeostasis and cancer. We determined the genetic variations of c-CBL, relationship to receptor tyrosine kinases (EGFR and MET), and functionality in NSCLC. METHODS AND FINDINGS Using ar...
متن کاملReceptor tyrosine kinases and targeted cancer therapeutics.
The majority of growth factor receptors are composed of extracellular, transmembrane, and cytoplasmic tyrosine kinase (TK) domains. Receptor tyrosine kinase (RTK) activation regulates many key processes including cell growth and survival. However, dysregulation of RTK has been found in a wide range of cancers, and it has been shown to correlate with the development and progression of numerous c...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2007
ISSN: 1556-0864
DOI: 10.1097/01.jto.0000282993.43307.94